Francesca Perego

Head of Department of Internal Medicine and Rehabilitation IRCCS ICS Maugeri, Milan – Italy

About Francesca Perego

Professional Profile
Title	Consultant in Internal Medicine and Geriatrics
Current Leadership Role	Head of Department of Internal Medicine and Rehabilitation
Institution	IRCCS ICS Maugeri, Milan – Italy
Summary	Senior Consultant Physician with extensive experience in Internal Medicine, Geriatrics, and Clinical Research. Currently Head of the Complex Operative Unit of Internal Medicine and Geriatrics and Chief of the Medical Rehabilitation Department at IRCCS ICS Maugeri (Milan). Internationally recognised expert in hereditary and acquired angioedema, principal investigator in multiple phase II–IV clinical trials, and author of over 70 peer-reviewed scientific publications.
Current Position
October 2022 – Present	IRCCS ICS Maugeri, Milan (Accredited Private Healthcare Institute); Head of the Complex Operative Unit of Internal Medicine and Geriatrics; Chief of the Internal Medicine and Rehabilitation Department; Permanent Consultant Contract (Senior Level – A11)
Previous Appointments
2019 – 2022	Head of Subacute Care Unit, IRCCS ICS Maugeri, Milan
2018 – 2019	Deputy Head of Unit, Subacute Care, IRCCS ICS Maugeri, Milan
2008 – 2018	Consultant in Internal Medicine and Emergency Medicine, Luigi Sacco Hospital, Milan (Public Healthcare)
2007 – 2008	Consultant in Internal Medicine (Fixed-term), Luigi Sacco Hospital, Milan
2005 – 2007	Freelance Consultant in Internal Medicine, Luigi Sacco Hospital, Milan
2004 – 2005	Emergency Department Physician, Vimercate Hospital
Education and Qualifications
PhD	Biomedical Statistics, University of Milan (70/70)
Specialisation	Internal Medicine, University of Milan (70/70)
MD Degree	Medicine and Surgery, University of Milan (110/110 cum laude)
Master’s Degree	Level I in Healthcare Management, University of Bergamo (110/110 cum laude)
Certification	Basic Ultrasound Certification (SIUMB)
Certification	ICH-GCP Certification – Faculty of Pharmaceutical Medicine, Royal College of Physicians (UK)
Clinical and Research Expertise
Areas	Internal Medicine and Geriatrics; Hereditary and Acquired Angioedema; Cardiovascular Autonomic Disorders and Syncope; Clinical Trial Design and Management (Principal Investigator); Diagnostic Ultrasound and Cardiovascular Testing
Scientific Societies and Leadership Roles
Roles	Board Member, Italian Network for Hereditary and Acquired Angioedema (ITACA); Member, ACARE – Angioedema Centres of Reference and Excellence; Member, Scientific Committee of SICOA; Former Regional Councillor, Italian Society of Internal Medicine (SIMI – Lombardy)
Selected Publications
1	Cancian M, Perego F, Senter R, Arcoleo F, De Pasquale T, Zoli A, Cicardi M, Zanichelli A. Pediatric angioedema: Essential features and preliminary results from the Hereditary Angioedema Global Registry in Italy. Pediatr Allergy Immunol. 2020 Feb;31 Suppl 24:22-24. doi: 10.1111/pai.13170.
2	Perego F, Gidaro A, Zanichelli A, Cancian M, Arcoleo F, Senter R, Bova M, De Pasquale T, Guarino MD, Lo Pizzo M, Frigerio C, Duca PG, Cicardi M; ITACA. Life expectancy in Italian patients with hereditary angioedema due to C1-inhibitor deficiency. J Allergy Clin Immunol Pract. 2020 Jan 16. doi: 10.1016/j.jaip.2020.01.007.
3	Riedl MA, Maurer M, Bernstein JA, Banerji A, Longhurst HJ, Li HH, Lu P, Hao J, Juethner S, Lumry WR, et al. Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks. Allergy. 2020 Nov;75(11):2879-2887. doi: 10.1111/all.14416.
4	Perego F, De Maria B, Bova M, Petraroli A, Marcelli Cesoni A, De Grazia V, Zingale LC, Porta A, Spadaro G, Dalla Vecchia LA. Analysis of Heart-Rate Variability during Angioedema Attacks in Patients with Hereditary C1-Inhibitor Deficiency. Int J Environ Res Public Health. 2021 Mar 12;18(6):2900. doi: 10.3390/ijerph18062900.
5	Johnston DT, Busse PJ, Riedl MA, Maurer M, Anderson J, Nurse C, Inhaber N, Yu M, Banerji A. Effectiveness of lanadelumab for preventing hereditary angioedema attacks: Subgroup analyses from the HELP study. Clin Exp Allergy. 2021 Oct;51(10):1391-1395. doi: 10.1111/cea.13974.
6	Guryanova I, Suffritti C, Parolin D, Zanichelli A, Ishchanka N, Polyakova E, Belevtsev M, Perego F, Cicardi M, Zharankova Y, Konoplya N, Caccia S, Gidaro A. Hereditary angioedema due to C1 inhibitor deficiency in Belarus: epidemiology, access to diagnosis and seven novel mutations in SERPING1 gene. Clin Mol Allergy. 2021 Apr 7;19(1):3. doi: 10.1186/s12948-021-00141-0.
7	De Maria B, Cassetti G, Clementi L, De Grazia V, Parati M, Perego F, Porta A, Dalla Vecchia LA. Autonomic cardiac profile in male and female healthcare professionals with and without preschoolers: differences evidenced by heart rate variability analysis. Sci Rep. 2022 Aug 25;12(1):14499. doi: 10.1038/s41598-022-18744-1.
8	De Maria B, Parati M, Bey Y, Dalla Vecchia LA, Perego F. Cardiovascular Autonomic Nervous System in a Patient With Hereditary Angioedema Affected by COVID-19. Cureus. 2024;16(3):e56449. doi: 10.7759/cureus.56449.
9	Riedl MA, Tachdjian R, Lumry WR, Craig T, Karakaya G, Gelincik A, Stobiecki M, Jacobs JS, Gokmen NM, Reshef A, Gompels MM, Manning ME, Bordone L, Newman KB, Treadwell S, Wang S, Yarlas A, Cohn DM. Efficacy and Safety of Donidalorsen for Hereditary Angioedema. N Engl J Med. 2024 May 31. doi: 10.1056/NEJMoa2402478.
10	Zanichelli A, Cattaneo D, Gidaro A, Senter R, Arcoleo F, Accardo P, Bignardi D, Borrelli P, Colangelo C, De Pasquale T, Firinu D, Perego F, Triggiani M, Spadaro G, Cogliati C, Bizzi E, Popescu Janu V, Guarino MD, Quattrocchi P, Brussino L, Rossi O, Triggianese P, Agolini S, Giardino F, Montinaro V, Cancian M. Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat. Front Pharmacol. 2025 Apr 25;16:1550133. doi: 10.3389/fphar.2025.1550133.
11	Senter R, Zanichelli A, Stefano A, Arcoleo F, Bignardi D, Borrelli P, Cogliati C, Colangelo C, De Pasquale T, Giacco SD, Firinu D, Gidaro A, Pizzo ML, Parente R, Perego F, Petraroli A, Janu VP, Pucci S, Quattrocchi P, Ridolfi I, Rossi O, Ruin F, Spadaro G, Triggianese P, Zoli A, Triggiani M, Cancian M. The Impact of COVID-19 on Patients With Bradykinin-Mediated Angioedema in the ITACA Cohort. Clin Exp Allergy. 2025 May 9. doi: 10.1111/cea.70079.
12	Riedl MA, Bernstein JA, Jacobs JS, Craig T, Banerji A, Perego F, Lumry WR, Wedner HJ, Gierer S, Manning ME, Bordone L, Treadwell S, Lin T, Newman KB, Yarlas A, Cohn DM. Donidalorsen Treatment of Hereditary Angioedema in Patients Previously on Long-Term Prophylaxis. J Allergy Clin Immunol Pract. 2025 Jul 17:S2213-2198(25)00599-9. doi: 10.1016/j.jaip.2025.06.018.
13	De Maria B, Ranucci L, Gino C, Zulueta A, Parati M, Cesoni Marcelli A, Zingale LC, Sideri R, Dalla Vecchia LA and Perego F. Cardiac and vascular autonomic control in patients with hereditary angioedema. Front Physiol. 2025;16:1690915. doi: 10.3389/fphys.2025.1690915.
14	Parati M, Ranucci L, Cesoni Marcelli A, Zingale LC, De Maria B, Gino C, Zulueta A, Sideri R, Gorini A and Perego F. Ecological momentary assessments for patients with hereditary angioedema: a feasibility and acceptability controlled study. Front Digit Health. 2026;7:1693550. doi: 10.3389/fdgth.2025.1693550.
15	De Maria B, Ranucci L, Gino C, Cesoni Marcelli A, Zingale LC, Zulueta A, Dalla Vecchia LA, Gorini A and Perego F. Functional physiological, psychological, and biochemical reactivity to socially evaluated cold pressor test in hereditary angioedema patients (FRoSEn). Front Immunol. 2026;16:1736589. doi: 10.3389/fimmu.2025.1736589.
16	Ranucci L, Perego F, Zulueta A, Gino C, Cesoni Marcelli A, Zingale LC, Dalla Vecchia LA, De Maria B and Gorini A. Behavioural withdrawal during an acute stress test as a marker of psychobiological vulnerability in hereditary angioedema. Front Immunol. 2026;17:1784326. doi: 10.3389/fimmu.2026.1784326.